Codeine 3-O-demethylase (EC 1.14.11.32, codeine O-demethylase, CODM) is an enzyme with systematic name codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating). This enzyme catalyses the following chemical reaction

codeine + 2-oxoglutarate + O2



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{\displaystyle \rightleftharpoons }
morphine + formaldehyde + succinate + CO2Codeine 3-O-demethylase contains Fe2+.

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